Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-α-defensins
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چکیده
منابع مشابه
Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro- -defensins SER2ILE PROTEOLYSIS ENABLES MEMBRANE-DISRUPTIVE ACTIVITY*
Colby S. Weeks, Hiroki Tanabe, Jason E. Cummings, Steve P. Crampton , Tanya Sheynis**, Raz Jelinek**, T. Kyle Vanderlick, Melanie J. Cocco , and Andre J. Ouellette ‡‡1 From the Departments of Pathology & Laboratory Medicine, Molecular Biology & Biochemistry, and Microbiology & Molecular Genetics, and Center for Immunology, University of California, Irvine, California 92697-4800, the Third Depar...
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Small intestinal Paneth cells secrete α-defensin peptides, termed cryptdins (Crps) in mice, into the intestinal lumen, where they confer immunity to oral infections and define the composition of the ileal microbiota. In these studies, facultative bacteria maintained under aerobic or anaerobic conditions displayed differential sensitivities to mouse α-defensins under in vitro assay conditions. R...
متن کاملPaneth cell α-defensins and enteric microbiota in health and disease
Antimicrobial peptides are major effectors of innate immunity of multicellular organisms including humans and play a critical role in host defense, and their importance is widely recognized. The epithelium of the intestine is the largest surface area exposed to the outer environment, including pathogens, toxins and foods. The Paneth cell lineage of intestinal epithelial cells produces and secre...
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Paneth cells at the base of small intestinal crypts secrete microbicidal α-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity. Proteomic studies show that five abundant Paneth cell α-defensins in C57BL/6 mice are strain specific in that they have not been identified in other inbred strains of mice. Two C57BL/6-specific peptides are coded for by the Defcr20 and -21 genes...
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*Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616; †Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226; ‡Department of Biological Sciences, California State University, Los Angeles, CA 90032; §Department of Medicine, David Geffen School of Medicine, University of California, Los Angele...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m602041200